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The importance of mold sensitivity in nonallergic rhinitis patients
Author(s) -
Demirtürk Mustafa,
Gelincik Aslı,
Ulusan Murat,
Ertek Belkıs,
Büyüköztürk Suna,
Çolakoğlu Bahattin
Publication year - 2016
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21731
Subject(s) - medicine , alternaria alternata , aspergillus fumigatus , allergen , tryptase , immunology , allergy , nose , immunoglobulin e , provocation test , alternaria , cladosporium , aspergillus , antibody , microbiology and biotechnology , pathology , surgery , botany , alternative medicine , mast cell , biology , genetics
Background In recent studies, local specific immunoglobulin E (sIgE) production against allergens in nasal mucosa and a positive response to a nasal allergen provocation test (NAPT) have been demonstrated in some patients initially diagnosed as nonallergic rhinitis (NAR) or idiopathic rhinitis (IR). The aim of this study was to evaluate the presence of local allergic rhinitis (LAR) in patients who experience rhinitis symptoms in indoor and outdoor moldy conditions and to investigate the role of the NAPT in diagnosis. Methods A total of 40 NAR patients with a history of persistent rhinitis and who had negative skin‐prick tests (SPTs) and serum sIgE levels to common aeroallergens, as well as 20 healthy subjects were included in the study. NAPTs were performed with Aspergillus fumigatus (group 1) or a mixture of Alternaria alternata and Cladosporium herbarum extracts (group 2). Results In patient nasal lavage fluids, tryptase and mold sIgE levels were not significantly different from the control group. NAPT with Aspergillus fumigatus was positive in 8 of 12 NAR patients (66.6%) in group 1 and NAPT with the mixture of extracts was positive in 9 of 13 NAR patients (69.2%) in group 2. Conclusion This study suggests that LAR may exist in a significant number of the persistent rhinitis patients who were previously considered as NAR based on negative SPTs or serum sIgE tests. To the best of our knowledge, this is the first study evaluating a nasal local allergic response to both indoor and outdoor molds.