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Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects
Author(s) -
Zhao Yali,
Zhang Yuan,
Zhang Luo
Publication year - 2016
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21725
Subject(s) - medicine , asthma , single nucleotide polymorphism , genotype , allele , genotyping , locus (genetics) , immunology , population , genetics , gene , biology , environmental health
Background Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify asthma susceptibility variants associated with AR in the Chinese population. Methods A cohort of 402 individuals with physician‐diagnosed AR and 416 healthy controls were recruited from the Han Chinese population in Beijing. DNA was extracted from the peripheral blood and a total of 12 single‐nucleotide polymorphisms (SNPs) shown to be associated with asthma in Japanese subjects were selected for genotyping using the SequenomMassARRAY technology platform. Results Analysis of frequency differences of allele between the AR patients and control subjects showed that the C allele of rs204993 in the pre‐B‐cell leukemia homeobox 2 (PBX2) gene from the 6p21.3 locus was significantly associated with AR ( p = 0.0006, p corrected = 0.0340). Genotype analysis further confirmed the difference in distribution of this variant between AR patients and controls in the both the dominant ( p T/C+C/C vs T/T = 7.37×10 −5 ) and co‐dominant ( p T/C vs T/T = 1.98 × 10 −4 , p C/C vs T/T = 0.004) models. Conclusion These results suggest that the PBX2 gene in the 6p21.3 asthma susceptibility locus may be associated with increased risk for both AR and asthma in Chinese subjects.