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Twenty‐two–item Sino‐Nasal Outcome Test in a control population: a cross‐sectional study and systematic review
Author(s) -
Farhood Zachary,
Schlosser Rodney J.,
Pearse Madeline E.,
Storck Kristina A.,
Nguyen Shaun A.,
Soler Zachary M.
Publication year - 2016
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21668
Subject(s) - medicine , confidence interval , asthma , chronic rhinosinusitis , population , meta analysis , cross sectional study , demography , pathology , environmental health , sociology
Background The 22‐item Sino‐Nasal Outcome Test (SNOT‐22) is a commonly utilized outcome measure for chronic rhinosinusitis (CRS). However, what constitutes a normal score remains poorly defined. The goal of this study was to evaluate SNOT‐22 scores in a control population without CRS and perform a systematic review and meta‐analysis of “normal” values. Methods Ninety‐nine subjects without CRS were enrolled, with 95 fully completing the SNOT‐22 questionnaire. Multivariable linear regression was used to determine whether demographic factors or medical comorbidities influence SNOT‐22 scores in a population without CRS. A systematic literature search was performed, identifying studies that evaluated the SNOT‐22 in a non‐CRS population and estimates for SNOT‐22 values were pooled. Results Thirty‐six males and 59 females were included in the primary analysis with a mean age of 53.4 ± 17.3 years (range, 18–88 years). The mean SNOT‐22 score was 16.4 ± 15.2. Asthma ( p = 0.003) and depression ( p = 0.002) were found to be independent predictors of higher SNOT‐22 scores. Thirteen articles were identified in the literature search and 1 was provided via author correspondence, with 10 reporting sufficient data to be included in the meta‐analysis. Weighted mean SNOT‐22 score was 11 ± 9.4 (n = 1517). Our data differed significantly from published data (mean difference = 5.4; 95% confidence interval [CI], 3.4 to 7.5; p < 0.0001) likely owing to differences in comorbidities. Conclusion SNOT‐22 scores vary in non‐CRS populations depending upon the group queried. Asthma and depression are associated with higher SNOT‐22 scores and should be considered when determining what constitutes a normal value.