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Functional Comorbidity Index in chronic rhinosinusitis
Author(s) -
Levine Corinna G.,
Davis Greg E.,
Weaver Edward M.
Publication year - 2016
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21620
Subject(s) - comorbidity , medicine , chronic rhinosinusitis , cohort , confounding , physical therapy
Background The Functional Comorbidity Index is a promising tool to predict general health status and adjust for comorbidity confounding in outcomes studies of chronic conditions, but it has been tested as a predictor of general health status only in a sleep apnea cohort. We tested it in a chronic rhinosinusitis cohort with 2 objectives: (1) measure the association between the Functional Comorbidity Index (range, 0 to 18) and general health status (SF‐36 Physical Component Score and Mental Component Score); and (2) test if the Functional Comorbidity Index is more strongly associated (a better predictor) than the well‐known Charlson Comorbidity Index (range, 0 to 37) with these SF‐36 outcome measures. Methods In a cross‐sectional study of chronic rhinosinusitis patients, we obtained scores for the Functional Comorbidity Index, Charlson Comorbidity Index, and the SF‐36. We calculated Spearman correlations and adjusted coefficients of determination ( R 2 ) using multiple linear regression, adjusted for demographic covariates. Bootstrapping generated R 2 distributions for statistical comparison. Results In the cohort (N = 97), the Functional Comorbidity Index scores (mean ± standard deviation: 2.2 ± 1.9) were more widely distributed than Charlson Comorbidity Index scores (0.6 ± 1.2). The Functional Comorbidity Index significantly correlated with the SF‐36 Physical Component Score (−0.49, p < 0.001) and Mental Component Score (−0.37, p < 0.001). The Functional Comorbidity Index was a better predictor than the Charlson Comorbidity Index of SF‐36 Physical Component Score ( R 2 mean ± standard error: 0.21 ± 0.09 vs 0.15 ± 0.05; p < 0.001) and Mental Component Score (0.16 ± 0.10 vs 0.01 ± 0.06; p < 0.001). Conclusion The Functional Comorbidity Index is a more robust predictor of general health status than the Charlson Comorbidity Index in chronic rhinosinusitis patients.