Premium
Dexamethasone affects mouse olfactory mucosa gene expression and attenuates genes related to neurite outgrowth
Author(s) -
Tian Jun,
Pinto Jayant M.,
Xin Yi,
Zhang Henghui,
Li Li,
Sun Zhifu,
Wei Yongxiang
Publication year - 2015
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21586
Subject(s) - olfaction , olfactory mucosa , medicine , gene , gene expression , axon , neurite , dexamethasone , olfactory system , endocrinology , biology , neuroscience , genetics , anatomy , in vitro
Olfaction is one of the important senses for humans. Systemic glucocorticoids are the most commonly used medications for olfactory loss because of their strong anti-inflammatory effects. However, their effect on olfactory function is still controversial and the precise mechanism is not clear. To gain a global view of the effect of systematic glucocorticoid treatment on gene expression in the olfactory mucosa (OM), we profiled these changes in a murine model of olfaction in order to identify underlying molecular mechanisms.