Dexamethasone affects mouse olfactory mucosa gene expression and attenuates genes related to neurite outgrowth | Zendy

Tian Jun | Zendy; Pinto Jayant M. | Zendy; Xin Yi | Zendy; Zhang Henghui | Zendy; Li Li | Zendy; Sun Zhifu | Zendy; Wei Yongxiang | Zendy

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Dexamethasone affects mouse olfactory mucosa gene expression and attenuates genes related to neurite outgrowth

Author(s) -

Tian Jun,

Pinto Jayant M.,

Xin Yi,

Zhang Henghui,

Li Li,

Sun Zhifu,

Wei Yongxiang

Publication year - 2015

Publication title -

international forum of allergy and rhinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.503

H-Index - 46

eISSN - 2042-6984

pISSN - 2042-6976

DOI - 10.1002/alr.21586

Subject(s) - olfaction , olfactory mucosa , medicine , gene , gene expression , axon , neurite , dexamethasone , olfactory system , endocrinology , biology , neuroscience , genetics , anatomy , in vitro

Olfaction is one of the important senses for humans. Systemic glucocorticoids are the most commonly used medications for olfactory loss because of their strong anti-inflammatory effects. However, their effect on olfactory function is still controversial and the precise mechanism is not clear. To gain a global view of the effect of systematic glucocorticoid treatment on gene expression in the olfactory mucosa (OM), we profiled these changes in a murine model of olfaction in order to identify underlying molecular mechanisms.

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