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Evaluation of vitamin D levels in allergic fungal sinusitis, chronic rhinosinusitis, and chronic rhinosinusitis with polyposis
Author(s) -
Mostafa Badr ElDin,
Taha Mohammed Shehata,
Abdel Hamid Tarek,
Omran Azza,
Lotfi Neema
Publication year - 2016
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21585
Subject(s) - medicine , chronic rhinosinusitis , sinusitis , chronic sinusitis , dermatology , nasal polyps , immunology
Background Vitamin D 3 (VD 3 ) levels have been recently found to be responsible for a number of immunological, anti‐inflammatory and anti‐infectious roles. Some studies reported that some forms of allergic fungal rhinosinusitis (AFRS), occurs more commonly in patients who are more susceptible to VD 3 deficiency. The aim of this work was to measure VD 3 levels in patients with AFRS and chronic rhinosinusitis (CRS). Methods We report a prospective case control study conducted at Ain Shams University. It included 74 participants divided into 4 groups: group A, 25 patients with AFRS; group B, 15 patients with CRS with nasal polyps (CRSwNP); group C: 15 patients with CRS without nasal polyps (CRSsNP); and group D, 19 controls. Results There was a statistically significant ( p < 0.001) difference of VD 3 between groups A and B compared with groups C and D. There were no statistically significant differences between the 4 groups regard calcium levels. Finally, there was a statistically significant difference in phosphate levels when we compared groups A and B with groups C and D ( p = 0.001). Conclusion Serum level of VD 3 in patient with CRSwNP and AFRS is significantly lower than that of patients with CRSsNP and control subjects. Although these results do not imply a specific etiological or therapeutic relationship, VD 3 levels may constitute an inexpensive prophylactic and cost‐effective option in the therapeutic armamentarium in the control of AFRS and CRSwNP, either by itself or as a synergistic agent with traditional agents.