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Nasal endoscopic evaluation and its impact on survival in patients with stage I/II extranodal natural killer/T‐cell lymphoma, nasal type
Author(s) -
Cho HyunJin,
Jang MinSeok,
Hong Sang Duk,
Kim Seok Jin,
Ahn Yong Chan,
Oh Dongryul,
Ko Young Hyeh,
Kim Hyo Yeol,
Dhong HunJong,
Chung SeungKyu,
Kim Won Seog
Publication year - 2015
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21564
Subject(s) - medicine , t cell lymphoma , lymphoma , hazard ratio , stage (stratigraphy) , confidence interval , gastroenterology , natural killer t cell , retrospective cohort study , univariate analysis , endoscopy , surgery , multivariate analysis , immunology , t cell , paleontology , immune system , biology
Background Endoscopic findings of extranodal natural killer/T‐cell lymphoma (ENKTL), nasal type, are heterogeneous, but not fully understood. The objective of this study was to evaluate the role of nasal endoscopic examination and its implications for treatment of stage I/II ENKTL. Methods This retrospective study included 60 consecutive patients diagnosed with stage I/II ENKTL, nasal type, from 2000 to 2011. Results The endoscopic findings were classified into early (45%) and advanced (55%) lesions. Furthermore, the primary tumor extent assessed by endoscopy was significantly correlated with the radiologic imaging ( p < 0.001). The results of univariate analysis showed that the patients with advanced lesions had worse overall survival ( p = 0.004) and disease‐free survival ( p = 0.001) than those with early lesions. In multivariate analysis, advanced lesions on nasal endoscopy was an independent prognostic factor ( p = 0.024; hazard ratio 5.29; 95% confidence interval, 1.25–22.39). Conclusion We found that nasal endoscopic findings were important prognostic factors in stage I/II ENKTL, nasal type, suggesting that comprehensive endoscopic evaluation of primary tumor should be performed in this setting.