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High‐dose sublingual immunotherapy in patients with uncontrolled allergic rhinitis sensitized to pollen: a real‐life clinical study
Author(s) -
Irani Carla,
Saleh Roula Abi,
Jammal Mouin,
Haddad Fady
Publication year - 2014
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21375
Subject(s) - medicine , asthma , slit , allergy , sublingual immunotherapy , sublingual administration , allergic asthma , population , allergen , immunology , genetics , biology , environmental health
Background High‐dose pollen sublingual immunotherapy (SLIT) is indicated in patients with moderate to severe allergic rhinitis (AR), especially those who are unable to control their disease with pharmacotherapy. We explore the use of high‐dose SLIT in patients with severe AR and sensitized to pollen, in real‐life clinical practice. We also analyzed the effect on asthma. Methods This was a prospective observational study conducted at the Allergy outpatient clinic at Hotel Dieu de France Hospital (HDF), Beirut, Lebanon. The cohort, composed of 118 patients between 7 and 55 years old, was regularly evaluated at inclusion, at 12 months, and at 36 months. Fifty‐five percent of AR patients had associated controlled asthma. Patients received a standardized pollen extract (Staloral 300IR). The pollen combination was 1 to 3 pollens, the most commonly used were Parietaria judaica , Cupressaceae , 5 grasses, and Oleaceae. In a previous study, those were the main allergenic pollens correlated to AR in the same population. Global assessment of the effect of SLIT was measured using a rhinitis total symptom score (RTSS), a rhinitis medication consumption score (RMCS), a global asthma score (ASS), and an asthma medication consumption score (AMCS). Results Using a t test we found that the average scores at inclusion, 12 months, and 36 months, respectively, were as follows: RTSS: 31.32, 16.39 ( p < 0.041), and 13.35 ( p < 0.041); RMCS: 6.96, 1.96 ( p < 0.0162), and 1.61 ( p < 0.0162); ASS: 4.62, 1.96 ( p < 0.0005), and 1.33 ( p < 0.0005); and AMCS: 2.35, 0.78 ( p < 0.0005), and 0.7 ( p < 0.0005). Conclusion Our study showed favorable results of SLIT to aeroallergens in patients with uncontrolled AR. The effect is also applicable to the subgroup of patients suffering from concomitant, controlled asthma.