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Chronic rhinosinusitis and sleep: a contemporary review
Author(s) -
Alt Jeremiah A.,
Smith Timothy L.
Publication year - 2013
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21217
Subject(s) - medicine , sleep (system call) , etiology , chronic rhinosinusitis , sinusitis , sleep disorder , disease , pathophysiology , nasal polyps , intensive care medicine , immunology , insomnia , psychiatry , computer science , operating system
Background Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as “sickness behavior.” Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is known about the underlying etiology and pathophysiology. This narrative review aims to further organize and present the current knowledge associating sleep and CRS. Methods A literature search was conducted of the OVID MEDLINE database using key search words including: “chronic rhinosinusitis,” “sleep,” “sleep disorders,” and “sleep dysfunction.” Additional keywords “nasal obstruction,” “nasal polyp,” and “fatigue” were identified and used to further delineate relevant articles. Results The articles that specifically addressed sleep and CRS were dissected and presented as follows: (1) chronic rhinosinusitis and sleep; (2) chronic rhinosinusitis and fatigue; (3) chronic rhinosinusitis, nasal obstruction, and sleep; and (4) pathophysiology of sleep in chronic rhinosinusitis (cytokines in both sleep and chronic rhinosinusitis and their association to the neuroimmune biology of chronic rhinosinusitis). Conclusion Patients with CRS have sleep dysfunction that is associated with their disease severity and overall quality of life. The etiology of sleep dysfunction in CRS is most likely multifactorial. Increasing evidence suggests sleep dysfunction in patients with CRS is partly due to the inflammatory disease process, and sleep physiology in patients with CRS may be actively regulated by the inflammatory component of the disease.