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Effect of intranasal budesonide irrigations on intraocular pressure
Author(s) -
Seiberling Kristin A.,
Chang Dennis F.,
Nyirady Janice,
Park Francine,
Church Christopher A.
Publication year - 2013
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.21180
Subject(s) - medicine , budesonide , intraocular pressure , glaucoma , nasal administration , corticosteroid , anesthesia , chronic rhinosinusitis , ophthalmology , surgery , immunology
Background Intranasal and oral corticosteroids are widely used in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). Higher‐dose topical nasal steroids (HDTNS) such as budesonide irrigations are increasingly used for long‐term maintenance in these patients. Oral steroids have the potential to cause increased intraocular pressure (IOP) and glaucoma. It is unclear whether HDTNS have the same potential. The objective of this study was to determine the effect of intranasal budesonide irrigations on IOP. Methods Two groups of patients with CRSwNP treated with budesonide irrigations were prospectively enrolled. Patients with history of elevated IOP or glaucoma were excluded. Patients in group 1 had been using budesonide for at least 1 month and had IOP measured once at the time of enrollment. Group 2 consisted of patients who were placed on budesonide at the time of enrollment and had IOP measured both before and after at least 4 weeks of therapy. Results Ten patients in group 1 and 8 patients in group 2 completed the study. In group 1, the average duration of therapy at enrollment was 6.3 months (1–22 months). Only 1 patient had a single eye pressure above 21 mmHg. None of the patients in group 2 had a significant change in IOP or IOP over 21 mmHg. Conclusion Intranasal budesonide irrigations given for a period of at least 1 month do not appear to increase IOP.