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Correlating matrix metalloproteinase‐9 sinus secretion levels with tissue biopsy levels
Author(s) -
Wilson Matt A.,
Orlandi Richard R.,
Firpo Matthew A.
Publication year - 2011
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.20043
Subject(s) - medicine , biopsy , secretion , matrix metalloproteinase , sinus (botany) , chronic rhinosinusitis , pathology , inflammation , biology , botany , genus
Background Collecting mucosal biopsies is invasive and creates additional inflammation, hampering a better understanding of nasal and sinus disease evolution and response to treatment. We examine whether sinus secretion collection can replace tissue biopsy for protein determination. Methods Prior to surgical intervention for chronic rhinosinusitis (CRS), a piece of gelatin foam was used to collect secretions from the ethmoid mucosa. A tissue biopsy was then taken from the same location. Matrix metallopro‐teinase‐9 (MMP‐9) protein levels were measured in each sample. Results MMP‐9 protein levels in secretions and tissues were significantly correlated ( p = 0.0033, r = 0.52, by Pearson correlation). Conclusion Secretion collection can replace tissue biopsy for MMP‐9 determinations, reducing morbidity. Furthermore, secretion collection allows sequential sampling from the same location. © 2011 ARS‐AAOA, LLC.