z-logo
Premium
Linkage disequilibrium patterns and genetic structure of Amerindian and non‐Amerindian Brazilian populations revealed by long‐range X‐STR markers
Author(s) -
Leite Fabio P.N.,
Santos Sidney E.B.,
Rodríguez Elzemar M.R.,
CallegariJacques Sidia M.,
Demarchi Dario A.,
Tsuneto Luiza T.,
PetzlErler M. Luiza,
Salzano Francisco M.,
Hutz Mara H.
Publication year - 2009
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.20998
Subject(s) - linkage disequilibrium , microsatellite , biology , genetic diversity , y chromosome , population , genetics , range (aeronautics) , linkage (software) , genetic structure , evolutionary biology , genetic variation , haplotype , gene , demography , genotype , allele , materials science , sociology , composite material
The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ∼86 Mb was investigated. The lower Amerindian gene diversity associated with significant differences between the populations studied indicated population structure as the main cause for the higher LD values in the Amerindian pool. On the other hand, the LD levels of the non‐Amerindian Brazilian sample, although less extensive than that of the Amerindians, were probably determined by admixture events. Our results indicated that different demographic histories have significant effects on LD levels of human populations, and provide a first approach to the X‐chromosome ancestry of Amerindian and non‐Amerindian Brazilian populations, being valuable for future studies involving mapping and population genetic studies. Am J Phys Anthropol 2009. © 2009 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here