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Comparative skeletal features between Homo floresiensis and patients with primary growth hormone insensitivity (Laron syndrome)
Author(s) -
Hershkovitz Israel,
Kornreich Liora,
Laron Zvi
Publication year - 2007
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.20655
Subject(s) - homo sapiens , consanguineous marriage , short stature , population , mutation , endocrinology , medicine , biology , consanguinity , genetics , gene , geography , archaeology , environmental health
Comparison between the skeletal remains of Homo floresiensis and the auxological and roentgenological findings in a large Israeli cohort of patients with Laron Syndrome (LS, primary or classical GH insensitivity or resistance) revealed striking morphological similarities, including extremely small stature and reduced cranial volume. LS is an autosomal recessive disease caused by a molecular defect of the Growth Hormone (GH) receptor or in the post‐receptor cascades. Epidemiological studies have shown that LS occurs more often in consanguineous families and isolates, and it has been described in several countries in South East Asia. It is our conclusion that the findings from the island of Flores, which were attributed to a new species of the genus Homo, may in fact represent a local, highly inbred, Homo sapiens population in whom a mutation for the GH receptor had occurred. Am J Phys Anthropol, 2007. © 2007 Wiley‐Liss, Inc.