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Argentine population genetic structure: Large variance in Amerindian contribution
Author(s) -
Seldin Michael F.,
Tian Chao,
Shigeta Russell,
Scherbarth Hugo R.,
Silva Gabriel,
Belmont John W.,
Kittles Rick,
Gamron Susana,
Allevi Alberto,
Palatnik Simon A.,
Alvarellos Alejandro,
Paira Sergio,
Caprarulo Cesar,
Guillerón Carolina,
Catoggio Luis J.,
Prigione Cristina,
Berbotto Guillermo A.,
García Mercedes A.,
Perandones Carlos E.,
PonsEstel Bernardo A.,
AlarconRiquelme Marta E.
Publication year - 2007
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.20534
Subject(s) - population stratification , ancestry informative marker , genetic admixture , population , population structure , geography , variance (accounting) , biology , demography , single nucleotide polymorphism , evolutionary biology , genetics , genotype , sociology , accounting , gene , business
Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies. Am J Phys Anthropol, 2007. © 2006 Wiley‐Liss, Inc.