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X‐linked hypophosphatemic rickets: A probable upper paleolithic case
Author(s) -
Formicola Vincenzo
Publication year - 1995
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330980403
Subject(s) - rickets , hypophosphatemic rickets , hyperostosis , etiology , skull , medicine , skeleton (computer programming) , hypophosphatemia , anatomy , hypophosphatasia , pathology , endocrinology , biology , vitamin d and neurology , biochemistry , alkaline phosphatase , enzyme
The skeleton of a middle‐aged adult male, found in the Late Epigravettian necropolis of Arene Candide cave (Italy) and dated to the XII millenniumB.C., exhibits abnormal changes, including bowing deformities, stunted growth, enthesopathies, and increased bone density. The pattern of the observed changes is less consistent with diagnoses of metaphyseal chondrodysplasias, hypophosphatasia, dietary rickets, or diffuse idiopathic skeletal hyperostosis (DISH) than with X‐linked hypophosphatemic rickets, which is the most likely etiological factor. This diagnosis may explain other abnormalities (exceptional elongation of the skull and bilateral absence of the lesser trochanter) displayed by other individuals from the same site. © 1995 Wiley‐Liss, Inc.