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Genomic reorganization and disrupted chromosomal synteny in the siamang ( Hylobates syndactylus ) revealed by fluorescence in situ hybridization
Author(s) -
Koehler Udo,
Arnold Norbert,
Wienberg Johannes,
Tofanelli Sergio,
Stanyon Roscoe
Publication year - 1995
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330970104
Subject(s) - hylobates , synteny , autosome , karyotype , biology , fluorescence in situ hybridization , genetics , chromosome , gene , zoology
We employed in situ hybridization (“chromosome painting”) of chromosome‐specific DNA libraries of all human chromosomes to establish homologies between the human and siamang karyotypes (Hylobates syndactylus, 2n = 50). Numerous intra‐ and interchromosomal rearrangements have led to a massive reorganization of the siamang karyotype. There have been a minimum of 33 translocations. The 24 siamang autosomes are composed of 60 recognizable segments that show DNA homology to regions of the 22 human autosomes. Only two autosomes have not been involved in translocations. The siamang presents a case, in a primate closely related to humans, in which chromosome morphology and synteny are highly disturbed in a manner similar to that encountered among rodents. © 1995 Wiley‐Liss, Inc.