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Genetic studies of human apolipoproteins. XVII: Population genetics of apolipoprotein polymorphisms in American Samoa
Author(s) -
Crews Douglas E.,
Kamboh Mohammad I.,
Bindon James R.,
Ferrell Robert E.
Publication year - 1991
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330840206
Subject(s) - genetics , biology , apolipoprotein b , allele , locus (genetics) , genetic variation , allele frequency , apolipoprotein e , population , gene , cholesterol , medicine , endocrinology , disease , environmental health
Variation in human apolipoprotein genes is a major source of phenotypic differences in human lipid metabolism. Data regarding genetic variation at apolipoprotein loci in various populations are only beginning to accumulate, and they suggest that different populations vary widely in distribution of apolipoprotein alleles. Using isoelectric focusing‐immunoblotting techniques, we screened 67 serum samples from self‐identified Samoan residents of American Samoa to investigate structural variation at six apolipoprotein loci: A‐I, A‐II, A‐IV, C‐II, E, and H. The APO A‐I, A‐II, and C‐II loci were found to be monomorphic by isoelectrical focusing. In Samoans, the common three‐allele polymorphism was observed for APO E, with no striking differences in frequencies from Caucasian populations. The three common alleles of the APO H locus also were identified; however, frequencies of the less common alleles (APO H * I and APO H *3) were different from those observed elsewhere for Caucasians.