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Blood genetic markers in the Chinese of two eastern provinces
Author(s) -
Saha N.
Publication year - 1989
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330800303
Subject(s) - phosphoglucomutase , mongoloid , allele , locus (genetics) , phosphogluconate dehydrogenase , allele frequency , biology , microbiology and biotechnology , lactate dehydrogenase , red blood cell , genetics , dehydrogenase , biochemistry , enzyme , gene , glucose 6 phosphate dehydrogenase , medicine , population , environmental health
Abstract A total of 205 Han Chinese from two eastern provinces (155 from Fujien and 50 from Hopeh) were tested for the distribution of six blood groups—A 1 A 2 BO, MN, Rhesus (CcDEe), Lewis a , Kell (Kk) and Fy a —four serum proteins—albumin and haptoglobin types; transferrin and groupspecific component subtypes—haemoglobin, and twelve red cell enzyme systems—glucose‐6‐phosphate dehydrogenase, 6‐phosphogluconate dehydrogenase, lactate and malate dehydrogenases; acid phosphatase, esterate‐D, glyoxalase I, adenylate kinase, glucose‐phosphate isomerase, phosphoglucomutase (locus 2), and superoxide dismutase types; and phosphoglucomutase (locus 1) subtypes. The frequencies of blood groups were more or less within the reported frequencies in the Chinese. However the frequency of le was much lower in the present series. The Chinese are characterized by low p 1 , Ro, k, le , and a high Fy a in general. P 2 was lacking in the Chinese. There were some differences in the blood group frequencies in the two provinces. The frequencies of Hp alleles; Tf and Gc subtypes show characteristic mongoloid features with high Hp 1 , Tf D , and Gc IF . The frequency of TF C2 was higher in the Fujien province than that in Hopeh. At the hemoglobin locus only one Hb AD was detected, while the frequency of the β‐thalassemia trait was 0.03. No red cell G6PD deficiency or variant was detected. The distribution of red cell enzymes showed Mongoloid characteristics with low PGD C , AK 2 , ESD 1 , GLO 1 , and higher P a . PGM 1 subtypes also had Mongoloid characteristics with lower PGM 2+ and higher PGM 2− . The phenotypic distribution of all the fifteen polymorphic loci was at Hardy ‐ Weinberg equilibrium in both the Chinese populations.