Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in Central Western Africa: A tentative hypothesis on the interaction between GPX1*2 and Hbβ*S allelic products | Zendy

DestroBisol Giovanni | Zendy; Spedini Gabriella | Zendy

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Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in Central Western Africa: A tentative hypothesis on the interaction between GPX1*2 and Hbβ*S allelic products

Author(s) -

DestroBisol Giovanni,

Spedini Gabriella

Publication year - 1989

Publication title -

american journal of physical anthropology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.146

H-Index - 119

eISSN - 1096-8644

pISSN - 0002-9483

DOI - 10.1002/ajpa.1330790209

Subject(s) - gpx1 , allele , genetics , polymorphism (computer science) , biology , glutathione peroxidase , glutathione , gene , enzyme , biochemistry

Phenotype and allele frequencies for erythrocyte glutathione peroxidase (GPX1) polymorphism are reported in the Mbugu and Sango (Central African Republic), Goun (Benin), and Bamileke (Cameroon) ethnic groups. The GPX1*2 allele frequencies (from 0.012 in the Sango to 0.058 in the Bamileke) fit into the range of the data already known for the Subsaharan populations. The value of GPX1*2 for study of the genetic admixture between Negro and Pygmy populations is suggested. Three different unusual GPX1 electrotypes are described. Finally, we hypothesize an interaction between GPX1*2 and Hb beta*S allelic products occurring in the sickle cells infected by Plasmodium falciparum .

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