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Genetic blood markers in Arab Druze of Israel
Author(s) -
Nevo Sarah
Publication year - 1988
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330770206
Subject(s) - abo blood group system , allele , genetics , biology , haplotype , rh blood group system , red cell , gene , allele frequency , blood type (non human) , chromosome , medicine , antibody
A sample of 153 individuals from a Druze village, in northern Israel, was typed for the following genetic markers—ABO, MNSs, Rh, P, Kell, and Duffy in the blood groups AcP, AK, ADA, EsD, GL01, ICD, LDH, G6PD, PGM 1 & 2, PHI, PGD and peptidases, A, B, C, and D in the red cell enzymes and for the serum proteins Hp and GC subtypes. Rare variants were observed in the following systems: PGD, a new slow variant, PGM, type 8‐1; Pep A, types 2‐1 and 3‐1, Pep B, type 2‐1; Pep D, types 3‐1 and 3‐3; and type GC, 2‐V. Significant deviations from Hardy‐Weinberg expectations were observed for MNSs and Duffy because of increased homozygosity, which was also observed in three other systems. Gene frequencies compared well with those of Arab Druze and Moslems in Lebanon and of Israeli Moslems in most of the systems, except for the lower frequencies of blood group B, the NS chromosome, the cde haplotype, and the AcP A allele in the present sample. A considerably lower frequency of the Fy allele was found in the Druze compared with Arab Moslems. It may be due to the Druze having been less exposed to inflow of African genes, to their being highlanders, and, therefore, less exposed to Plasmodium vivax malaria, or to both of the above.