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Distribution of red cell phosphoglucomutase‐1 subtypes in several mongoloid populations of East Asia
Author(s) -
Saha N.
Publication year - 1988
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330770114
Subject(s) - thais , mongoloid , phosphoglucomutase , allele frequency , locus (genetics) , allele , genetics , east asia , china , biology , geography , traditional medicine , demography , population , medicine , gene , biochemistry , archaeology , sociology , enzyme
The distribution of red cell phosphoglucomutase (PGM) subtypes was determined by starch‐gel electrophoresis and isoelectric focusing in a group of 2,484 unrelated individuals from ten Mongoloid populations of East Asia. The sample comprised 998 Chinese from various localities—Singapore, 325; Malaysia, 270; Taiwan, 276; Hong Kong, 67; Fouzhou, 60—as well as 342 Koreans; 252 Filipinos; 529 Thais; 336 Malays, and 27 Indonesians. Altogether 15 phenotypes controlled by four common and five rare alleles at the PGM 1 locus were observed in these populations. The frequency of the most frequent allele ( PGM 1 ) varied from 0.56 to 0.74, with the highest frequency observed in the Singapore Chinese and the lowest in the Malays. Within the Chinese from different localities a significant degree of heterogeneity was observed at the PGM 1 locus. The rare allele ( PGM 1 7) 6 was observed only among the Chinese, Thais, and Malays, while the PGM 1 was lacking in the Filipinos. A new allele with ahigh pI (6.5) was observed in a low frequency in all the populations but the Malays.