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Gc (vitamin D binding protein) subtype polymorphism and variants distribution among Saharan, Middle East, and African populations
Author(s) -
Constans J.,
LefevreWitier Ph.,
Richard P.,
Jaeger G.
Publication year - 1980
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330520315
Subject(s) - allele , polymorphism (computer science) , biology , genetics , gene , allele frequency , distribution (mathematics) , mathematical analysis , mathematics
This article presents the results obtained by electrophoretic analysis of the group specific component polymorphism in more than 1,250 serum samples from populations living in the Sahara, the Middle East, and equatorial Africa. In addition to the alleles Gc IF and Gc IS , five variants, including one previously unknown, were found. The distribution of the alleles herein described permits speculation on exchanges and relation among the groups considered. The lowest frequencies of the gene Gc 2 correspond to regions where sunlight is stronger. There is also a north‐south gradient in the Gc IF gene frequency. This seems to parallel the gradient seen in skin pigmentation.