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Distribution of HLA antigens in Polish and German populations in Milwaukee, Wisconsin
Author(s) -
Stevenson Joan C.,
Duquesnoy René J.
Publication year - 1979
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330500103
Subject(s) - haplotype , german , human leukocyte antigen , biology , african descent , genetics , antigen , gene , allele , geography , history , genealogy , archaeology
Gene and haplotype frequencies for HLA‐A and HLA‐B antigens were determined in Milwaukee blood donors of German and Polish descent. Gene frequencies for A25 and B18 were significantly higher in Poles than in Germans. Significant gametic associations were noted for A1‐B8, A29‐B12 and AW30‐B13 in both populations. Gametic association for A3‐B7 was only found in Germans, while the A25‐B18 haplotype frequency was significantly increased in Poles. Since the latter haplotype has also been found in Yugoslavs, Ukrainians and Czechs, it is possible that A25‐B18 represents a Slavonic marker.