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The genetic hypothesis for the transmission of Australia antigen (HBsAg)
Author(s) -
Smith David Glenn
Publication year - 1978
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330490214
Subject(s) - hbsag , penetrance , biology , transmission (telecommunications) , genetics , evolutionary biology , gene , computer science , hepatitis b virus , phenotype , telecommunications , virus
Exceptions have been cited which rule against the simple autosomal recessive hypothesis for the transmission of susceptibility to infection with Australia antigen (HBsAg). An attempt is made here to present a genetic model for a complex segregation analysis of a new and unique set of data to test this hypothesis. Regression techniques were used to estimate in four populations, age and sexspecific penetrance levels and the frequency of the gene whose product is hypothesized to be HBsAg. While the genetic hypothesis was not in general supported, observed deviations and their possible causes are discussed.