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Linkage disequilibrium in Bougainville Island
Author(s) -
Cadien James D.,
Hassett Matthew J.,
Friedlaender Jonathan S.
Publication year - 1978
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330480305
Subject(s) - linkage disequilibrium , disequilibrium , locus (genetics) , covariance , genetics , biology , natural selection , linkage (software) , allele , statistics , evolutionary biology , demography , haplotype , population , mathematics , gene , medicine , sociology , ophthalmology
Linkage disequilibria are estimated for three 2‐locus systems in 18 samples from Bougainville Island, Solomon Islands. The systems are haptoglobin, acid phosphatase and MN blood group. The disequilibria are estimated two ways: by maximum likelihood (ML) and by the covariance between the non‐alleles. Though seven of the 52 ML estimates are statistically different than zero, none of the covariance estimates are significant. We conclude that because linkage disequilibrium for loosely linked loci is a small quantity and because the sample sizes for most populations studied by anthropologists are small, linkage disequilibrium will not be a useful parameter for the study of natural selection in these populations.