Premium
The effect of sample attrition on the frequency distribution of blood pressure and genetic marker phenotypes representing a natural unselected community: Tecumseh, Michigan
Author(s) -
Smith David G.,
Sing Charles F.
Publication year - 1976
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330440120
Subject(s) - attrition , demography , blood pressure , sample (material) , population , phenotype , biology , medicine , genetics , gene , chemistry , dentistry , chromatography , sociology
Abstract Highly significant differences in mean age, blood pressure and phenotype frequency distributions between the non‐migrants and “emigrants” of a total unselected community sample were discovered. Use of the mean of BP scores collected from epidemiologic surveys over a period of time as an individual score allows sample attrition to produce both a genetically and demographically biased sample of a population intended to represent an unselected community of people. Multiple regression analyses estimated the contribution of an individual's age, genotype and mobility out of the sample to predicting blood pressure variation. Variation in blood pressure means among certain marker phenotype classes was greater in those who leave than in those who stay, but only the upper portion of the pressure distribution contributed to this relationship. A genetic‐environment interaction is suggested.