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Transferrins, haptoglobins, and ceruloplasmins among tribal groups of Madagascar
Author(s) -
BuettnerJanusch John,
Reisman Richard,
Coppenhaver Dorian,
Mason George A.,
BuettnerJanusch Vina
Publication year - 1973
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330380303
Subject(s) - haptoglobin , ceruloplasmin , plateau (mathematics) , transferrin , allele frequency , phenotype , allele , latitude , biology , geography , genetics , immunology , biochemistry , gene , mathematical analysis , mathematics , geodesy
Transferrin phenotypes of 403 Malagasy were determined by autoradiography after electrophoresis of plasma or serum. Three phenotypes, Tf C, Tf CD, and Tf D, were found. The frequency of Tf D was 0.051 in the total sample, 0.041 in tribes of the Madagascar plateau, and 0.075 in tribes of the coastal and lowland regions. Haptoglobin phenotypes of 402 Malagasy were determined. The frequency of Hp 1 was 0.41 in the total sample, 0.38 in tribes of the plateau, and 0.49 in coastal‐lowland tribes. There is a significant difference in the frequency of Hp 1 between the tribes of the plateau and those of the coastal and lowland regions. This confirms earlier observations of significant differences in frequencies of haptoglobins and hemoglobin S. Plasma or serum samples from 405 Malagasy were examined by electrophoresis to determine ceruloplasmin phenotypes. Seven distinct ceruloplasmin bands were observed. These were A, B, Galveston, Bridgeport, New Haven, Tananarive, and X, the last two described for the first time. Ten different phenotypes composed of one or two of the bands were observed. The frequency of the allele for ceruloplasmin B ( CpB ) was 0.78 in the total sample, 0.73 in tribes of the plateau, and 0.92 in coastal and lowland tribes. There is a significant difference in the frequency of this allele in the two major tribal groups, and this provides additional evidence of genetic differences between the peoples of the plateau and those of the coast and lowland regions of Madagascar.