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The frequency of isoniazid acetylase enzyme deficiency among Egyptians
Author(s) -
Hashem Nemat,
Khalifa Sami,
Nour Assma
Publication year - 1969
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330310114
Subject(s) - isoniazid , enzyme , allele , heterozygote advantage , incidence (geometry) , allele frequency , medicine , chemistry , microbiology and biotechnology , biochemistry , pharmacology , biology , tuberculosis , pathology , gene , physics , optics
The frequency of isoniazid slow inactivators is very high among Eqyptians, 82% have more than 0.91 γ/ml of free INH in serum specimens obtained six hours after a single dose of 10 mgm/kgm. The incidence of the allele for INH acetylase enzyme deficiency is estimated at 0.9059 and that of the heterozygous carrier of this allele at 0.1705.