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Hemoglobin, glucose‐6‐phosphate dehydrogenase, phosphogluconate dehydrogenase and adenylate kinase polymorphism in Moslems in Iran
Author(s) -
Bowman James E.,
Ronaghy Hossain
Publication year - 1967
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330270203
Subject(s) - dehydrogenase , adenylate kinase , phosphogluconate dehydrogenase , hemoglobin , glucose 6 phosphate dehydrogenase , population , allele , allele frequency , biology , microbiology and biotechnology , lactate dehydrogenase , biochemistry , chemistry , enzyme , medicine , gene , environmental health
Abstract Starch‐gel electrophoresis of blood samples from 322 Moslems in Shiraz, Iran was performed for hemoglobins, glucose‐6‐phosphate dehydrogenase, phosphogluconate dehyrogenase, and adenylate kinase. Rh blood types were also studied in a similar population. The only abnormal hemoglobin found was hemoglobin D; the estimated allele frequency for D was 0.006. The glucose‐6‐phosphate dehydrogenase electrophoretic pattern of erythrocytes was predominnately the B phenotype in unaffected Moslems; a similar phenotype was found in leukocyte extracts of two G6PD deficient males. The A glucose‐6‐phosphate dehydrogenase band was found in low frequency in this non‐African population. Allele frequency estimates of phosphogluconate dehydrogenase B and of adenylate kinase 2 were comparable to those found in Europeans and in their descendents and were unlike those of aboriginal African populations. The Rh allele frequencies were: R 1 , 0.508; R 2 , 0.161; R 0 , 0.055; and r , 0.264.