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Distribution of blood antigens A, B, and D in the population of bogotá (analysis of 30,000 samples)
Author(s) -
Fajardo Luis F.,
Lavalle Zaray N.
Publication year - 1966
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/ajpa.1330240215
Subject(s) - abo blood group system , rh blood group system , haemolytic disease , population , rh isoimmunization , medicine , antigen , immunology , pregnancy , immunization , typing , obstetrics , antibody , biology , fetus , microbiology and biotechnology , genetics , environmental health
As tested by anti‐A and anti‐B sera, blood drawn from 30,000 inhabitans of Bogotá, Colombia, showed the following phenotype percentages: A — 26.5, B — 8.0, AB — 1.1, and O — 64.4. The allele frequencies were: A — 0.150, B — 0.048, and O — 0.802. In the same samples anti‐D (Rh 0 ) was used: 94.6% of the individuals carried the D antigen. All bloods were typed with fresh commercial sera. No back‐typing was performed. Hemolytic disease of the newborn, caused by Rh‐Hr isoimmunization, is more frequent (0.40%) in Bogotá than should be expected for a population having only (5.4%) or less “Rh negative” individuals. This paradoxical fact was observed in the analysis of 12,672 deliveries in an obstetrical hospital of Bogotá. A possible explanation could be the multiparity of Colombian women since the possibility of isoimmunization and hemolytic disease increases with each succeeding pregnancy in a given woman. Also it is well established that when Rh‐Hr incompatibility is combined with ABO incompatibility, it is less apt to produce disease than when it occurs alone. AO isoimmunization should therefore be less frequent in Bogotá than in populations that have a higher frequency of A individuals. Thus, the women of Bogotá are less “protected” from Rh‐Hr immunization by ABO incompatibility.