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Ovarian reserve tests and their utility in predicting response to controlled ovarian stimulation in rhesus monkeys
Author(s) -
Wu Julie M.,
Takahashi Diana L.,
Ingram Donald K.,
Mattison Julie A.,
Roth George,
Ottinger Mary Ann,
Zelinski Mary B.
Publication year - 2010
Publication title -
american journal of primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 81
eISSN - 1098-2345
pISSN - 0275-2565
DOI - 10.1002/ajp.20823
Subject(s) - ovarian reserve , stimulation , hormone , follicle stimulating hormone , test (biology) , medicine , endocrinology , biology , luteinizing hormone , ecology , infertility , pregnancy , genetics
Controlled ovarian stimulation (COS) is an alternative to natural breeding in nonhuman primates; however, these protocols are costly with no guarantee of success. Toward the objective of predicting COS outcome in rhesus monkeys, this study evaluated three clinically used ovarian reserve tests (ORTs): day 3 (d3) follicle‐stimulating hormone (FSH) with d3 inhibin B (INHB), the clomiphene citrate challenge test (CCCT), and the exogenous FSH Ovarian Reserve Test. A COS was also performed and response was classified as either successful (COS+) or unsuccessful (COS−) and retrospectively compared with ORT predictions. FSH and INHB were assessed for best hormonal index in conjunction with the aforementioned tests. INHB was consistently more accurate than FSH in all the ORTs used. Overall, a modified version of the CCCT using INHB values yielded the best percentage of correct predictions. This is the first report of ORT evaluation in rhesus monkeys and may provide a useful diagnostic test before costly follicle stimulations, as well as predicting the onset of menopause. Am. J. Primatol. 72:672–680, 2010. © 2010 Wiley‐Liss, Inc.