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Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause
Author(s) -
Voytko Mary Lou,
Tinkler Gregory Paul,
Browne Carole,
Tobin Joseph R.
Publication year - 2009
Publication title -
american journal of primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 81
eISSN - 1098-2345
pISSN - 0275-2565
DOI - 10.1002/ajp.20705
Subject(s) - menopause , estrogen , neurocognitive , neuroprotection , hormone therapy , cognition , medicine , clinical trial , psychology , physiology , cognitive aging , neuroscience , bioinformatics , biology , cancer , breast cancer
Many postmenopausal women question whether to start or continue hormone therapy because of recent clinical trial negative results. However, evidence from other studies of postmenopausal women, and from studies in menopausal monkeys, indicate that estrogen has neurocognitive protective effects, particularly when therapy is initiated close to the time of menopause before neural systems become increasingly compromised with age. In this review, we present studies of menopausal women and female monkeys that support the concept that estrogen therapies protect both cognitive function and neurobiological processes. Am. J. Primatol. 71:794–801, 2009. © 2009 Wiley‐Liss, Inc.