Premium
Neuroendocrine regulation of prolactin secretion in adult female rhesus monkeys during different phases of the menstrual cycle: role of neuroexcitatory amino acid (NMA)
Author(s) -
Jahan S.,
Jalali S.,
Shami S.A.
Publication year - 2007
Publication title -
american journal of primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 81
eISSN - 1098-2345
pISSN - 0275-2565
DOI - 10.1002/ajp.20357
Subject(s) - prolactin , endocrinology , medicine , luteal phase , secretion , nmda receptor , glutamate receptor , follicular phase , menstrual cycle , receptor , biology , hormone
The present study attempts to examine the role of N‐methyl‐D, L‐aspartate (NMDA) receptors in the central regulation of prolactin (PRL) secretion, which may be involved in ovarian function and its alteration by glutamate in various phases of the menstrual cycle of female rhesus monkeys ( Macaca mulatta ). The results suggest that the glutaminergic component of the control system, which governs PRL secretion by utilizing NMDA receptors, may have an important role in regulating changes in PRL secretion. The response of PRL during the luteal phase of the cycle was different from that observed in follicular and menstrual phases. Steroids may influence the NMDA‐dependent drive to release PRL. N‐methyl‐D‐aspartic acid (NMA) involvement in the regulation of PRL secretion may occur through activation of the PRL‐stimulating system depending on the physiological state or steroidal milieu. It is possible, therefore, that the NMA‐induced release of PRL‐releasing factors (PRF) and PRL are enhanced in the presence of ovarian feedback. Am. J. Primatol. 69:1–12, 2007. © 2006 Wiley‐Liss, Inc.