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An Efficient Approach to Access 2,2‐Diarylanilines via Visible‐Light‐Promoted Decarboxylative Cross‐Coupling Reactions
Author(s) -
Luo Cong,
Zhou Tongyao,
Wang Wei,
Han Pan,
Jing Linhai
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100458
Subject(s) - chemistry , indoline , conjugate , combinatorial chemistry , visible spectrum , yield (engineering) , aryl , photochemistry , decarboxylation , catalysis , organic chemistry , optoelectronics , mathematical analysis , physics , materials science , mathematics , alkyl , metallurgy
A straightforward protocol for the visible‐light‐promoted decarboxylative 1,6‐conjugate addition of N ‐aryl glycines to para ‐quinone methides under transition‐metal‐free conditions is disclosed. This method provides scalable and efficient access to 2,2‐diarylanilines with biological and pharmacologic potential in good to excellent yields (39 examples, up to 97% yield). The synthetic utility of this work has been illustrated in the efficient synthesis of 3‐substituted indoline.