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Pd‐Catalyzed Cascade Heck‐Type Annulation And Carbonylation to β ‐Oxindolysulfoximidoyl Amides at Room Temperature
Author(s) -
Liu Huahua,
Xiong Yuping,
Chen Zhiyuan
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100451
Subject(s) - chemistry , annulation , intramolecular force , carbonylation , catalysis , cascade , heck reaction , medicinal chemistry , combinatorial chemistry , trapping , organic chemistry , palladium , ecology , chromatography , carbon monoxide , biology
An efficient intramolecular Heck annulation and trapping of the resulting cyclic α‐oxindolylpalladium species by CO (1 atm) and N H‐sulfoximine in a cascade protocol at room temperature was described, which offering 3,3‐disubstituted β‐indoly sulfoximidoyl amides in mostly excellent yields under very gentle reaction conditions.