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Nickel Catalyzed Ligand‐ And Base‐Free One‐Pot Diazotization/Cross‐Coupling of Aryl Amine With Aryl Boronic Acid
Author(s) -
Bej Ansuman,
Saha Debajyoti
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100437
Subject(s) - chemistry , aryl , amine gas treating , ligand (biochemistry) , catalysis , boronic acid , combinatorial chemistry , base (topology) , nickel , coupling reaction , organic chemistry , nitrite , polymer chemistry , mathematical analysis , biochemistry , alkyl , receptor , mathematics , nitrate
A Ni‐catalyzed ligand, acid and base free one‐pot method for the synthesis of unsymmetrical biaryls from anilines has been shown for the first time via an in‐situ diazotization reaction using tert‐butyl nitrite ( t ‐BuONO). The procedure is convenient and safer since it does not involve the isolation of diazonium salts. This method tolerates a wide range of functionalized anilines and aryl boronic acids with both electron donating and electron withdrawing groups leading to the formation of corresponding biaryl products in moderate to good yields.