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Palladium(II)‐Catalyzed N ‐Carbonylative Cross‐Coupling Reaction of Sulfoximines with Aryl, Heteroaryl, and Alkenyl Halides Using Tungsten Hexacarbonyl as Carbon Monoxide Source
Author(s) -
Han Sang Hoon,
Lee Kyungsup,
Noh Hee Chan,
Lee Phil Ho
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100388
Subject(s) - chemistry , aryl , chemoselectivity , palladium , carbon monoxide , halide , acylation , catalysis , bromide , monoxide , carbonylation , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl
Palladium(II)‐catalyzed N ‐acylation was demonstrated through the reaction of N−H sulfoximines with a variety of aryl, heteroaryl, and aryl halides using W(CO) 6 as a source of carbon monoxide, affording N ‐acylated sulfoximines in good to excellent yields. Moreover, alkenyl bromides underwent palladium(II)‐catalyzed N ‐acylation reactions with N−H sulfoximines, leading to the formation of N ‐cinnamoyl sulfoximines. This method has the advantages of a broad substrate scope, high functional group tolerance, simple operation, and chemoselectivity between chloride and bromide.