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Facile Synthesis of Oleanane‐type Pentacyclic Triterpenoids Bearing Hydroxy Groups on D/E Rings
Author(s) -
Mu Tong,
Xu Peng,
Yu Biao
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100316
Subject(s) - oleanane , chemistry , triterpenoid , oleanolic acid , hydroxylation , stereochemistry , triterpene , organic chemistry , medicine , alternative medicine , pathology , enzyme
Pentacyclic triterpenoids (PTs) comprise one of the largest class of natural products; many bear higher oxidation state on the D/E rings and exhibit a wide range of biological activities. Here, we report the chemical synthesis of a series of oleanane‐type PTs bearing hydroxy groups on D/E rings from the largely available oleanolic acid by transformations following site‐selective C−H hydroxylation.
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