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Metal‐ and Additive‐Free C3‐Functionalization of Imidazo[1,2‐ a ]pyridines with para ‐Quinone Methides
Author(s) -
Lafzi Ferruh,
Kilic Haydar
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100313
Subject(s) - chemistry , surface modification , nucleophile , quinone , alkylation , substrate (aquarium) , metal , functional group , combinatorial chemistry , scope (computer science) , organic chemistry , medicinal chemistry , catalysis , oceanography , polymer , computer science , programming language , geology
Metal‐ and additive‐free C3‐alkylation of imidazo[1,2‐ a ]pyridines with para ‐quinone methides ( p ‐QMs) has been realized. 1,6‐Nucleophilic addition of imidazopyridines to p ‐QMs were carried out under mild conditions in very excellent yields. Furthermore, we performed late‐stage drug functionalization for zolimidine. All transformations proceeded with broad substrate scope and good functional group tolerance.