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Visible‐Light Mediated Metal‐Free Cross‐Electrophile Coupling of Isatin Derivatives with Electron‐Poor Alkenes
Author(s) -
Maji Kakoli,
Rai Pramod,
Maji Biplab
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100308
Subject(s) - chemistry , electrophile , alkene , isatin , photochemistry , visible spectrum , transition metal , amine gas treating , radical , organic chemistry , catalysis , physics , optoelectronics
A transition metal‐free cross‐electrophile coupling of isatins with acceptor‐substituted alkene has been developed. The reaction operates at room temperature utilizing abundant amine as the terminal reductant under visible light irradiation. A large number of γ‐hydroxy esters and γ‐butyrolactones were synthesized in moderate to good yields tolerating a broad range of functional groups.