Organocatalyst‐promoted Diastereoselective and Enantioselective Michael Addition/Hemiketalization Reaction between Hydroxymaleimide and Quinone | Zendy

Xiang Min | Zendy; Li ChenYi | Zendy; Zhang Jian | Zendy; Zou Ying | Zendy; Huang ZhiCheng | Zendy; Li WenSheng | Zendy; Wang Yi | Zendy; Tian Fang | Zendy; Wang LiXin | Zendy

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Organocatalyst‐promoted Diastereoselective and Enantioselective Michael Addition/Hemiketalization Reaction between Hydroxymaleimide and Quinone

Author(s) -

Xiang Min,

Li ChenYi,

Zhang Jian,

Zou Ying,

Huang ZhiCheng,

Li WenSheng,

Wang Yi,

Tian Fang,

Wang LiXin

Publication year - 2021

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.202100291

Subject(s) - chemistry , enantioselective synthesis , michael reaction , organocatalysis , succinimide , quinone , catalysis , organic chemistry , combinatorial chemistry

An organocatalyst promoted diastereoselective and enantioselective Michael addition/hemiketalization reaction between hydroxymaleimides and quinones has been demonstrated. The catalytic protocol allows for the efficient and mild synthesis of a broad range of new and versatile dihydrobenzofurans containing chiral hemiketal and succinimide frameworks from readily available starting materials in moderate to excellent yields (up to 95%) with good to excellent enantioselectivities (up to 95 : 5 er) and diastereoselectivities (all with at least 99 : 1 dr).

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