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Selective Synthesis of Trisubstituted Imidazoles by Iodine‐Catalyzed [3+2] Cycloadditions
Author(s) -
Zhan Zhenzhen,
Zhang Mingming,
Jiang Pengbo,
He Jianping,
Luo Nan,
Wang Hesong,
Wang Meng,
Huang Guosheng
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100287
Subject(s) - chemistry , cycloaddition , catalysis , iodine , combinatorial chemistry , compatibility (geochemistry) , reaction conditions , organic chemistry , chemical engineering , engineering
In this paper, two novel and efficient methods for the synthesis of trisubstituted imidazoles have been developed through iodine‐catalyzed [3+2] cycloaddition. By controlling one of the reaction materials, we selectively synthesized 1,2,4‐trisubstituted imidazoles and 1,2,5‐trisubstituted imidazoles. The desired products were obtained in moderate to good yields with wide functional groups compatibility under standard conditions.