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Recent Studies of Bifunctionalization of Simple Indoles
Author(s) -
Wang ZhanYong,
Xu Shaohong,
Wang KaiKai,
Kong Niuniu,
Liu Xue
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100280
Subject(s) - chemistry , carbocation , nucleophile , indole test , nucleophilic addition , combinatorial chemistry , organic chemistry , catalysis
Indole structures are extremely important and widely employed in organic synthesis. This review will focus on direct bifunctionalizations of simple indoles in tandem reactions. Recent studies have been divided into four types by trigger mechanisms: (1) nucleophilic C3; (2) nucleophilic NH for cyclization; (3) reduction; (4) oxidation. Reactions with carbocations, pyridines, alkenes, alkynes, aldehydes, imines, halogenated compounds et al were discussed. We hope this review will promote future research in the use of indoles.