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Ruthenium (VIII) Catalysed Dearomative Pyridyl C−X Activation: Direct Synthesis of N ‐ Alkyl‐2‐pyridones
Author(s) -
Das Biswajit,
Rout Nilendri,
Sarkar Debayan
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100258
Subject(s) - chemistry , alkyl , ruthenium , catalysis , combinatorial chemistry , scope (computer science) , medicinal chemistry , organic chemistry , computer science , programming language
An efficient synthetic strategy employing pyridyl C−X activation, for the generation of N ‐alkyl‐2‐pyridones from N ‐alkyl‐2‐halopyridinium salts is described. As pyridones are dearomatised synthetic derivatives of pyridines, a versatile scope exist for pyridyl C−H functionalisation. The present strategy exemplifies a straight forward in‐situ generation of Ru(VIII), leading catalytic dearomative synthesis of pyridones. The N ‐alkyl‐2‐pyridones are further reduced to N ‐alkyl‐2‐piperidones and a plausible mechanism is also drawn, which is supported by some controlled reactions.