Premium
Oxidative [3+2] Annulation of Pyridinium Salts with gem ‐Difluoroalkenes: Synthesis of 2‐Fluoroindolizines
Author(s) -
Yang Li–Miao,
Zhang YouYa,
Deng JingTong,
Ma AiJun,
Zhang XiangZhi,
Zhang ShuYu,
Peng JinBao
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100253
Subject(s) - pyridinium , chemistry , annulation , oxidative phosphorylation , combinatorial chemistry , pyridinium compounds , organic chemistry , base (topology) , catalysis , biochemistry , mathematical analysis , mathematics
An oxidative [3+2] annulation of pyridinium salts with gem ‐difluoroalkenes for the synthesis of highly substituted 2‐fluoroindolizines has been developed. Using DBU as base, a broad range of multisubstituted 2‐fluoroindolizines were prepared in good to excellent yields under mild conditions, and many useful functional groups can be tolerated.