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Na 2 Eosin Y Catalyzed Alkylation of Enol Acetates by Radical Decarboxylation of N‐Hydroxyphthalimide Esters
Author(s) -
Nie Yu,
Wang Zechao,
Feng Zengqiang,
Dong Bingbing,
Bai Yuyang,
Leng Yuting,
Wu Junliang
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100248
Subject(s) - chemistry , decarboxylation , alkylation , enol , eosin y , catalysis , organic chemistry , eosin , functional group , medicinal chemistry , staining , medicine , polymer , pathology , photocatalysis
A novel, efficient and transition‐metal‐free alkylation of enol acetates by radical decarboxylation of N‐hydroxyphthalimide esters to synthesize α‐alkylated ketones in existence of Na 2 ‐eosin Y at room temperature has been developed. This methodology features operational simplicity, mild reaction conditions, widely functional group tolerance, affording a diverse array of α‐alkylated ketones in moderate to good yields.