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Rhodium‐Catalyzed Synthesis of Isoquinolino[1,2‐ b ]Quinazolines via C−H Annulation in Biomass‐Derived γ ‐Valerolactone
Author(s) -
Wang Liang,
Jiang Kuanchang,
Zhang Nana,
Zhang Zhihui
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100247
Subject(s) - annulation , chemistry , rhodium , catalysis , oxidizing agent , acetylene , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry
A rhodium‐catalyzed synthesis of isoquinolino[1,2‐ b ]quinazolines via C−H annulation using vinylene carbonate as an oxidizing acetylene surrogate in biomass‐derived γ ‐valerolactone (GVL) has been developed. The reactions proceeded smoothly to give the corresponding products in moderate to good yields without any external oxidant and base. This protocol can also be applied for the synthesis of 5,6‐dihydro‐8 H ‐isoquinolino[1,2‐ b ]quinazolin‐8‐ones.