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N ‐Methoxy arenesulfonamide as a Sulfonyl Equivalent For Palladium‐Catalyzed Sulfonylation of Arenes Through C−H Activation
Author(s) -
Ojha Subhadra,
Panda Niranjan
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100246
Subject(s) - sulfonyl , chemistry , palladium , catalysis , aryl , combinatorial chemistry , cleavage (geology) , bond cleavage , molecule , stereochemistry , medicinal chemistry , organic chemistry , alkyl , geotechnical engineering , fracture (geology) , engineering
The prevalence of sulfones in natural products, pharmaceutically active molecules and functional materials draw immense attention for their synthesis. Here, we report a palladium‐catalyzed protocol for synthesizing diaryl sulfones from the arenes through C−H activation. N ‐methoxy arenesulfonamide was exploited as a potential sulfonyl donor by the cleavage of S−N bond through a radical pathway. The present methodology has several advantages: a simple, readily available catalytic system; the use of a stable sulfonyl donor; a relatively moderate excess of arene coupling partner for an undirected C−H activation process, along with the tolerances of aryl bromides and iodides, which in turn permits further cross‐coupling reactions to afford cross‐coupled sulfones.