Premium
Silver‐Catalyzed Direct Regioselective C3 Phosphonation of 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones With H ‐phosphites
Author(s) -
Guo Lina,
Su Meiyun,
Zhan Haiying,
Liu Wenjie,
Wang Shaohua
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100235
Subject(s) - regioselectivity , chemistry , catalysis , compatibility (geochemistry) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , chemical engineering , engineering
An efficient and simple protocol for silver‐catalyzed direct C3 phosphonation of 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones with dialkyl phosphites has been developed. The reaction shows high regioselectivity, broad scope of substrates, and good functional group compatibility. Importantly, the phosphorylated 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐one product 3 u can be employed as efficient probes for Fe 3+ .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom