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Base Promoted Intramolecular O ‐arylation For The Synthesis of Dibenzo[ b , f ]oxepinones Toward Dihydroartocarpol D
Author(s) -
Li Kaili,
Zhang Kun,
Huang He,
Zhang Qianqian,
Song Chuanjun,
Chang Junbiao
Publication year - 2021
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.202100227
Subject(s) - chemistry , intramolecular force , base (topology) , medicinal chemistry , stereochemistry , combinatorial chemistry , mathematics , mathematical analysis
An efficient base‐promoted intramolecular O ‐arylation approach of 2‐halobenzyl 2‐hydroxyphenyl ketones toward the synthesis of dibenzo[ b , f ]oxepinones has been developed. The products are obtained in good to excellent isolated yields. Further extension of the strategy to the total synthesis of dihydroartocarpol D has been described.
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